A Flask is a microframework build for small applications with more straightforward requirements. Flask comes ready to use.

Pyramids are built for larger applications. They provide flexibility and allow the developer to use the right tools for their projects. The developer is free to choose the database, templating style, URL structure, and more. Pyramids is configurable.

Similar to Pyramids, Django can be used for larger applications. It includes an ORM.

BY Best Interview Question ON 13 Jan 2019